P1vital CNS Experimental Medicine : CO2 MODEL

CO2 challenge inducing anxiety READ MORE:

In patients with panic disorder the anxiety resulting from a CO2 challenge has been shown to be sensitive to treatment with acute or chronic treatment with the benzodiazepine alprazolam.

Although much of the published literature on CO2 -induced anxiety has focused on panic anxiety in patients with panic disorder researchers at Bristol led by Prof David Nutt have reported that the inhalation of 7.5% CO2 in healthy subjects produces an increase in blood pressure and heart rate, and increased feelings of anxiety, fear and tension (Bailey et al 2005).

The model has been validated with the benzodiazepine lorazepam and the results replicated in a number of independent studies. Recently the SSRI paroxetine has also been shown to have positive effects in this model.