P1vital CNS Experimental Medicine : DENTAL PHOBIA

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Dental phobia affects about 20% of the population leading to dental neglect. Eventually, patients in whom dental neglect results in chronic pain present to hospital dental units where treatment is normally administered under sedation.

Not surprisingly patients with dental phobia have high levels of anxiety on the day of the procedure; which can be effectively reduced by alprazolam. However, recently obtained pilot data suggests that levels of anxiety increase in the days leading up to treatment. These data indicate that anxiety levels begin to increase approximately 3-4 days before the procedure and peak immediately before surgery begins.

The advantage of this assay is that the anxiety induced is pathological and chronic with a low signal to noise ratio.